✦ LIBER ✦

Radiosynthesis of [N-methyl-11C]methylene blue

✍ Scribed by Lutz Schweiger; Stuart Craib; Andrew Welch; Peter Sharp

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 103 KB
Volume: 46
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.784

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In this paper we present the radiochemical synthesis of the novel compound [N‐methyl‐^11^C]methylene blue. The synthesis of [N‐methyl‐^11^C]methylene blue was accomplished by means of ^11^C‐methylation of commercially available Azure B using [^11^C]methyl trifluoromethanesulfonate ([^11^C]methyl triflate). Following purification [N‐methyl‐^11^C]methylene blue was obtained with a radiochemical purity greater than 97% in a 4–6% decay corrected radiochemical yield. The synthesis was completed in an average of 35 min following the end of bombardment. Copyright © 2003 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Radiosynthesis of [11C]-N-methylacyclovi

Radiosynthesis of [11C]-N-methylacyclovir

✍ Alan A. Wilson; Peter S. Conti; Robert F. Dannals; Hayden T. Ravert; Henry N. Wa 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 158 KB

## Abstract A selective and potent analogue of the anti‐herpes agent acyclovir has been labelled with ^11^C in good yield and at high specific activities. 1‐[^11^C]‐Methyl‐9‐(2‐hydroxyethoxy)methyl)guanine may be useful for detecting HSV encephalitis using positron emission tomography.

Radiosynthesis of [11C]nifedipine and [1

Radiosynthesis of [11C]nifedipine and [11C]nicardipine

✍ Alan A. Wilson; Robert F. Dannals; Hayden T. Ravert; H. Donald Burns; Susan Z. L 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 491 KB

The radiosyntheses of the dihydropyridine (DHP) calcium channel blockers [IlCInifedipine and [I 1Clnicardipine by alkylation of the appropriate DHP 3-monocarboxylic acid anion with [ 11CIiodomethane are described. Isolated radiochemical yields of 30-50% were obtained 25 minutes after the end-of-bomb

Radiosynthesis of [11C]paclitaxel

✍ Hayden T. Ravert; Raymond W. Klecker Jr; Jerry M. Collins; William B. Mathews; M 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 94 KB

## Abstract [^11^C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [__α__‐^11^C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioacti

Radiosynthesis of [11C]docetaxel

✍ E. W. van Tilburg; E. J. F. Franssen; J. J. M. van der Hoeven; M. van der Meij; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 166 KB

## Abstract Docetaxel (Taxotere®) is an accepted chemotherapeutic agent for the treatment of breast cancer and non‐small cell lung cancers. A potential means of predicting response is measuring tumor uptake of [^11^C]docetaxel using Positron Emission Tomography (PET). The synthetic approach to intr

Further investigation on the radiosynthe

Further investigation on the radiosynthesis of α-[11C]methyl-tryptophan

✍ Makiko Suehiro; Hayden T. Ravert; Alan A. Wilson; Ursula Scheffel; Robert F. Dan 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 415 KB

## Abstract Improved procedures for the radiosynthesis of α‐[^11^C]methyltryptophan and α‐[^11^C]methyl‐tryptophan methyl ester were studied. Following α‐deprotonation of tryptophan methyl ester benzaldimine with LDA, 60 – 80% of no carrier added [^11^C]iodomethane was incorporated in 5 minutes at

Solid-phase radiosynthesis of [11C]WAY 1

Solid-phase radiosynthesis of [11C]WAY 100635

✍ Alan A. Wilson; Jean N. DaSilva; Sylvain Houle 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

An efficient, fast and simple method is described for the radiosynthesis of the potent and selective ~- [11C]Iodomethane was effectively trapped on a C18 reverse-phase cartridge at ambient temperature where it reacted rapidly with the normethyl precursor, N-[2-[4-(2- hydroxypheny1)-1 -piperazinyl]e