✦ LIBER ✦

Radiosynthesis of [11C]nifedipine and [11C]nicardipine

✍ Scribed by Alan A. Wilson; Robert F. Dannals; Hayden T. Ravert; H. Donald Burns; Susan Z. Lever; Henry N. Wagner Jr.

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 491 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580270513

No coin nor oath required. For personal study only.

✦ Synopsis

The radiosyntheses of the dihydropyridine (DHP) calcium channel blockers [IlCInifedipine and [I 1Clnicardipine by alkylation of the appropriate DHP 3-monocarboxylic acid anion with [ 11CIiodomethane are described. Isolated radiochemical yields of 30-50% were obtained 25 minutes after the end-of-bombardment, with specific activities of 400-1400 mCi/pmol at the end-of-synthesis. A variety of positron emitting DHPs with different ester side chains in the 3 and 5 positions on the DHP ring may be prepared by this approach using currently available labelled alkylating agents.

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