𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Radiosynthesis of [11C]paclitaxel

✍ Scribed by Hayden T. Ravert; Raymond W. Klecker Jr; Jerry M. Collins; William B. Mathews; Martin G. Pomper; Richard L. Wahl; Robert F. Dannals

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
94 KB
Volume
45
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

[^11^C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α‐^11^C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity. Copyright © 2002 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Radiosynthesis of [11C]docetaxel
Radiosynthesis of [11C]docetaxel
✍ E. W. van Tilburg; E. J. F. Franssen; J. J. M. van der Hoeven; M. van der Meij; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 166 KB

## Abstract Docetaxel (Taxotere®) is an accepted chemotherapeutic agent for the treatment of breast cancer and non‐small cell lung cancers. A potential means of predicting response is measuring tumor uptake of [^11^C]docetaxel using Positron Emission Tomography (PET). The synthetic approach to intr

Radiosynthesis of [11C]nifedipine and [1
Radiosynthesis of [11C]nifedipine and [11C]nicardipine
✍ Alan A. Wilson; Robert F. Dannals; Hayden T. Ravert; H. Donald Burns; Susan Z. L 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 491 KB

The radiosyntheses of the dihydropyridine (DHP) calcium channel blockers [IlCInifedipine and [I 1Clnicardipine by alkylation of the appropriate DHP 3-monocarboxylic acid anion with [ 11CIiodomethane are described. Isolated radiochemical yields of 30-50% were obtained 25 minutes after the end-of-bomb

Radiosynthesis of [11C]-N-methylacyclovi
Radiosynthesis of [11C]-N-methylacyclovir
✍ Alan A. Wilson; Peter S. Conti; Robert F. Dannals; Hayden T. Ravert; Henry N. Wa 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 158 KB

## Abstract A selective and potent analogue of the anti‐herpes agent acyclovir has been labelled with ^11^C in good yield and at high specific activities. 1‐[^11^C]‐Methyl‐9‐(2‐hydroxyethoxy)methyl)guanine may be useful for detecting HSV encephalitis using positron emission tomography.

Radiosynthesis of [11C]ximelagatran via
Radiosynthesis of [11C]ximelagatran via palladium catalyzed [11C]cyanation
✍ Anu J. Airaksinen; Jan Andersson; Phong Truong; Olle Karlsson; Christer Halldin 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 208 KB

## Abstract __N__‐hydroxyamidines (amidoximes) may be used in prodrug technology in improving oral bioavailability of drugs containing amidino functional groups. In the body, amidoximes are reduced quickly to amidines by enzymes that are present in several organs. Ximelagatran is a benzamidoxime an

Solid-phase radiosynthesis of [11C]WAY 1
Solid-phase radiosynthesis of [11C]WAY 100635
✍ Alan A. Wilson; Jean N. DaSilva; Sylvain Houle 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

An efficient, fast and simple method is described for the radiosynthesis of the potent and selective ~- [11C]Iodomethane was effectively trapped on a C18 reverse-phase cartridge at ambient temperature where it reacted rapidly with the normethyl precursor, N-[2-[4-(2- hydroxypheny1)-1 -piperazinyl]e

Radiosynthesis of 1-[11C] polyhomoallyli
Radiosynthesis of 1-[11C] polyhomoallylic fatty acids
✍ Michael A. Channing; Norman Simpson 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 328 KB

## Abstract A facile retro‐synthesis involving the radical chain decarboxylation of the N‐hydroxypyridine‐2‐thione esters of both arachidonic and docosahexaenoic acid was utilized to synthesize (all Z)‐1‐bromononadeca‐4,7,10,13‐tetraene, and (all Z)‐1‐bromoheneicosa‐3,6,9,12,15,18‐hexaene in 60% ov