✦ LIBER ✦

Radiosynthesis of 1-[11C] polyhomoallylic fatty acids

✍ Scribed by Michael A. Channing; Norman Simpson

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 328 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330611

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✦ Synopsis

Abstract

A facile retro‐synthesis involving the radical chain decarboxylation of the N‐hydroxypyridine‐2‐thione esters of both arachidonic and docosahexaenoic acid was utilized to synthesize (all Z)‐1‐bromononadeca‐4,7,10,13‐tetraene, and (all Z)‐1‐bromoheneicosa‐3,6,9,12,15,18‐hexaene in 60% overall yield. The corresponding polyhomoallylic magnesium bromides were carbonated with [^11^C]CO~2~ to afford the 1‐[^11^C]polyhomoallylic labeled fatty acids in good yield in less than 35 minutes. The final radiochemical purities were found to be in excess of 95% by radio‐HPLC.

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