✦ LIBER ✦

Solid-phase radiosynthesis of [11C]WAY 100635

✍ Scribed by Alan A. Wilson; Jean N. DaSilva; Sylvain Houle

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 301 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199602)38:2<149::aid-jlcr824>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

An efficient, fast and simple method is described for the radiosynthesis of the potent and selective ~-

[11C]Iodomethane was effectively trapped on a C18 reverse-phase cartridge at ambient temperature where it reacted rapidly with the normethyl precursor, N-[2-[4-(2- hydroxypheny1)-1 -piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexane carboxamide. Following high performance liquid chromatography purification and formulation, [IICIWAY 100635 was obtained in high radiochemical yields (40%, uncorrected from [11C]Iiodomethane) in a synthesis time of 25 min with an average specific actvity of (at end-ofsynthesis) 33 GBq/pmole (900 mCi/pmole).

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