✦ LIBER ✦

Synthesis of D-[1-14C]penicillamine hydrochloride

✍ Scribed by David H. T. Chien; David A. Ebert; Robert W. Roth

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 228 KB
Volume: 25
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580251102

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✦ Synopsis

SUlIpIARY

Methods

are described for the synthesis of DL-[1-14C]penicillamine and D-[1-14C]penicillamine hydrochloride from K%N. of H14CN to 2,2,5,5-tetramethyl-3-thiazoline followed by hydrolysis of the resulting thiazolidine to DL-penacillamine. Resolution was achieved through the salt of N-formylisopropylidene-DL-penicillamine with (-)-norephedrine. cific activity of D-penicillamine was 21.7 mCi/mmole and the overall radiochemical yield from K 1 ' C N was 3 . 3 % .

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