## Abstract Ractopamine HCl was uniformly labeled with carbonโ14 in one of two phenyl rings as a requirement for animal metabolism studies. The sixโstep synthesis was completed in a 14% yield. Product instability on silica gel complicated purification, but development of a chromatographic method af
A synthesis of [14C]alfuzosine hydrochloride
โ Scribed by J. Allen
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 158 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
Labelled w i t h catbon-14 wan nynthe-4hed in h i g h ouch& yield dmm p o t a n h i m [ 14C]cyunaCe doh p h m a c o k i n d c and me,tabvLbm h t u d i a .
Alfuzosine hydrochloride, ~-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl] tetrahydro-2-furancarboxamide hydrochloride, hereinafter referred to as SL 77.499 hydrochloride 1 1 is a drug undergoing development which possesses blood pressure lowering properties (antihypertensive agent).
๐ SIMILAR VOLUMES
Drotaverinum hydrochloride was labelled with 14C isotope in position 1 of the isoquinoline ring. A rapid synthesis with high radiochemical yield was elaborated. ~ \* Kl'CN was prepared by BBnfi's method5 4C -Drotaverinwn Hydrochloride
Two 14C preparations o f t h e Hz-antagonist e t i n t i d i n e hydrochloride a r e reported. I n one, t h e l a b e l I s introduced by r e a c t i n g [1-I4C] propargylamine w i t h t h e a p p r o p r i a t e i s o t h i ourea, f o l l o w e d by h y d r o c h l o r i d e formation. This a f f
SUlIpIARY ## Methods are described for the synthesis of DL-[1-14C]penicillamine and D-[1-14C]penicillamine hydrochloride from K%N. of H14CN to 2,2,5,5-tetramethyl-3-thiazoline followed by hydrolysis of the resulting thiazolidine to DL-penacillamine. Resolution was achieved through the salt of N-f
[2] [3] [4]N dibutylamino propoxy) 3,S-dirnethyl benzoyl] chromone, was synthesized from (U-14C) oxalic acid. The labelling takes place at the first step of the synthesis, and allowed the obtention o f -14C-Bucromarone succinate, with a specific activity o f 7.45 mCi/mmol, i.e. 275.6 MBq/mmol ; -
## Abstract For studies of pharmacokinetics and drug metabolism of the new orally active, selective phosphodiesterase type V (PDE V) inhibitor vardenafil (Levitra^ยฎ^), the ^14^Cโlabelled version was synthesised. Starting from the cyanation of 2โiodophenol with K^14^CN, an 8โstep synthesis led to tw