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Synthesis of 14C-radiolabeled ractopamine hydrochloride

✍ Scribed by Norman H. Terando

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 311 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310903

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✦ Synopsis

Abstract

Ractopamine HCl was uniformly labeled with carbon‐14 in one of two phenyl rings as a requirement for animal metabolism studies. The six‐step synthesis was completed in a 14% yield. Product instability on silica gel complicated purification, but development of a chromatographic method afforded ractopamine ·HCl‐^14^C with a radiochemical purity of 98.2%.

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