✦ LIBER ✦

Radiolabeled antimalarials: Synthesis of 14C-artemisinin

✍ Scribed by Mitchell A. Avery; Jason D. Bonk; James Bupp

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 194 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199603)38:3<263::aid-jlcr839>3.0.co;2-o

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✦ Synopsis

The stereoselective total synthesis of the antimalarial agent 14C-(+)-artemisinin (l), incorporating I4C at C-16 (C-9 methyl) is reported, in 18% radiochemical yield from acid 3.

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