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Deuterated antimalarials: Synthesis of trideutero-artemisinin, dihydroartemisinin, and arteether

✍ Scribed by Mitchell A. Avery; Jason D. Bonk; Sanjiv Mehrotra

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 247 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199603)38:3<249::aid-jlcr840>3.0.co;2-d

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✦ Synopsis

The stereoselective total synthesis of the antimalarial agents artemisinin-dg (1). dihydroartemisinin-d3 (2), and arteether-dg (3), incorporating ZH at C-16 (C-9 methyl) is reported.

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