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ChemInform Abstract: Synthesis and Structure—Activity Relationships of Peroxidic Antimalarials Based on Artemisinin

✍ Scribed by Mitchell A. Avery; Maria Alvim-Gaston; John R. Woolfrey

Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Design, Synthesis, Derivatization, and Structure—Activity Relationships of Simplified, Tricyclic, 1,2,4-Trioxane Alcohol Analogues of the Antimalarial Artemisinin.
✍ J. N. CUMMING; D. WANG; S. B. PARK; T. A. SHAPIRO; G. H. POSNER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

Alcohol Analogues of the Antimalarial Artemisinin. -A series of the title compounds such as (VIII)-(XI) is synthesized and used in the preparation of derivatives such as (XIII). These products are potent antimalarials with up to 140% of the efficacy of the natural artemisinin. -(CUMMING,