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ChemInform Abstract: Design, Synthesis, Derivatization, and Structure—Activity Relationships of Simplified, Tricyclic, 1,2,4-Trioxane Alcohol Analogues of the Antimalarial Artemisinin.

✍ Scribed by J. N. CUMMING; D. WANG; S. B. PARK; T. A. SHAPIRO; G. H. POSNER

Publisher: John Wiley and Sons
Year: 2010
Weight: 37 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199827214

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✦ Synopsis

Alcohol Analogues of the Antimalarial Artemisinin.

-A series of the title compounds such as (VIII)-(XI) is synthesized and used in the preparation of derivatives such as (XIII). These products are potent antimalarials with up to 140% of the efficacy of the natural artemisinin. -(CUMMING,

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