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Design and Synthesis of Orally Active Dispiro 1,2,4,5-Tetraoxanes; Synthetic Antimalarials with Superior Activity to Artemisinin.

✍ Scribed by Richard Amewu; Andrew V. Stachulski; Stephen A. Ward; Neil G. Berry; Patrick G. Bray; Jill Davies; Gael Labat; Livia Vivas; Paul M. O'Neill


Publisher
John Wiley and Sons
Year
2007
Weight
17 KB
Volume
38
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Design, Synthesis,
✍ J. N. CUMMING; D. WANG; S. B. PARK; T. A. SHAPIRO; G. H. POSNER πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 37 KB πŸ‘ 1 views

Alcohol Analogues of the Antimalarial Artemisinin. -A series of the title compounds such as (VIII)-(XI) is synthesized and used in the preparation of derivatives such as (XIII). These products are potent antimalarials with up to 140% of the efficacy of the natural artemisinin. -(CUMMING,