✦ LIBER ✦

Synthesis and biodistribution of 14C-radiolabelled hypocrellin B

✍ Scribed by Jixiang Liu; Gerald G. Miller; Liren Huang; Zhenjun Diwu; J. William Lown; Kevin Brown; Ronald B. Moore; John Tulip; Malcolm S. McPhee

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 395 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580360902

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Our research group is currently exploring the use of hypocrellins as potential photosensitizers for photodynamic therapy (PDT). The purpose of this study is to investigate the synthesis and biodistribution of ^14^C‐labelled Hypocrellin B. Radiolabelled hypocrellin‐B (HB) with the ^14^C atom incorporated in either or both the 4‐ and 13‐methoxy groups was synthesized with a specific activity of 2.11 mCi per mmol. The purified, ^14^C‐HB, prototype photodynamic therapy photosensitizer was used to determine the kinetics of uptake in EMT6/Ed cells in monolayer culture, and the kinetics of tumor and tissue distribution in Balb/c mice bearing the EMT6/Ed tumor.

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