Prami racetam (C 1-879; N-CP-Cbi s ( 1-met hyl e t h y l ) ami n o l e t h y l I-2-0x0-1p y r r o l i d i n e a c e t a m i d e ) was r a d i o l a b e l e d w i t h tritium. e t h y l 2,5-di hydro-2-oxo-l~-pyrrole-l-acetate i n t h e presence o f PdfC gave e t h y l 2-0~0-1-[3,4-3H]pyrrolidineaceta
Synthesis of 14C-labeled pramiracetam hydrochloride, N-[2-(bis[1-methylethyl]amino)ethyl]-2-oxo-1-pyrrolidine-acetamide-α-14C hydrochloride, CI-879 hydrochloride
✍ Scribed by Jon D. Hartman; C. C. Huang; D. E. Butler
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 221 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Synthesis of I4C-Labeled Pramiracetam Hydrochloride, E-[2-(Bis[ 1-me thyle thyl 1 aminole thyl ] -2-0x0-l -p y r r o l i d i n eac.etamide-a-14C Hydrochloride, CI-879 Hydrochloride1
📜 SIMILAR VOLUMES
## Abstract The title compound 9 was prepared by the route outlined in Scheme I. [^14^C]Thiourea (1) was condensed with ethyl 4‐bromo‐3‐oxo‐2‐methoxyiminoacetate (2), providing ethyl 2‐(2‐amino‐4‐[2‐^14^C]thiazolyl)‐2‐methoxyiminoacetate (3), as the pure Z‐isomer. Saponification gave the amino acid
## Abstract The preparation of ^14^C labelled 1‐(4‐chlorophenyl)‐2‐methy 1‐2‐aminopropane hydrochloride is described. The radioactive carbon was introduced into the central position of the aminopropyl group in order to study the pharmacological properties and mode of action of the anorexigenic drug
The title compound, CGS 148248, was synthesized with a '%-label in the azepine ring in 14 steps starting with l-bromo-3-phenylpropane (1> and K1%N in an overall yield of 1.31%. The reaction of I with K 1 k N yielded the nitrile 2 which upon hydrolysis followed by ring closure gave a-tetral~ne-l-~~c
The partial ergoline LY228729 (1) which was a potent 5HT 1A agonist has been studied clinically. Somewhat later, a related analog, (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4-tetrahydronaphthalen-2-yl)amine (2a) which in addition to potent 5HT 1A agonist activity was a muscarinic antagonist, was chosen