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The synthesis of 14C-labelled 1-(4-chlorophenyl) -2-methyl-2-amino-propane hydrochloride (chlorphentermine, Desopimon®)

✍ Scribed by J. Engler; L. Pallos

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
170 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of ^14^C labelled 1‐(4‐chlorophenyl)‐2‐methy 1‐2‐aminopropane hydrochloride is described. The radioactive carbon was introduced into the central position of the aminopropyl group in order to study the pharmacological properties and mode of action of the anorexigenic drug. The synthesis started from Ba^14^CO~3~, involved 3 steps, and a radiochemical yield of 23% was obtained. The chemical and radiochemical purity of the end‐product was proved by thin layer chromatography and autoradiography.

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