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Synthesis of 14C-labelled (S)-(+)-2-[4-(p-fluorobenzoyl)-1-piperidyl]-1-naphthylethanol hydrochloride

✍ Scribed by Norio Karibe; R. M. Rosser; Masataka Ueda; Hachiro Sugimoto

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
236 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^14^C‐labelled (S)‐(+)‐2‐[4‐(p‐fluorobenzoyl)‐1‐piperidyl]‐1‐naphthylethanol hydrochloride (5), an anti‐ischemic drug, was synthesized for studying the pharmacokinetic profiles of the compound in four steps using 2‐[carbonyl‐^14^C]acetonaphthone (1) as a labelled starting material.

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