## Abstract The preparation of ^14^C labelled 1‐(4‐chlorophenyl)‐2‐methy 1‐2‐aminopropane hydrochloride is described. The radioactive carbon was introduced into the central position of the aminopropyl group in order to study the pharmacological properties and mode of action of the anorexigenic drug
Synthesis of 14C-labelled compounds of biological interest: 4-methyl-2-pyridyl-2-furamide hydrochloride /MEPAF/
✍ Scribed by Zofia Ozdowska
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 232 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A method of carbon‐^14^C introduction into the molecule of a new drug 4‐methyl‐2‐pyridyl‐2‐furamide hydrochloride /MEPAF/ has been elaborated and furan‐2‐^14^C‐carboxylic acid has been synthesized. Radioactivity distribution and chemical yields in this synthesis were established.
📜 SIMILAR VOLUMES
## Abstract The synthesis of 2,4‐diamino‐5‐phenylthiazole hydrochloride labelled with carbon – 14 in the 2‐position has been effected whereby the ^14^C‐label was introduced in the last step. The overall yields were 34.5% (gravimetrically) and 32.8% (radiochemically).
## Abstract Mepindolol, a potent ß‐adrenoceptor blocking agent, was labelled with ^14^C by two different routes yielding the 2‐[^14^C]methyl and [2‐^14^C] products. While the first alternative was abandoned because of low overall yield, the latter route provided mepindolol with a specific activity
## Abstract ^14^C‐labelled (S)‐(+)‐2‐[4‐(p‐fluorobenzoyl)‐1‐piperidyl]‐1‐naphthylethanol hydrochloride (5), an anti‐ischemic drug, was synthesized for studying the pharmacokinetic profiles of the compound in four steps using 2‐[carbonyl‐^14^C]acetonaphthone (1) as a labelled starting material.
## Abstract 1‐(4‐Chlorobenzyl)‐3‐methyl‐3‐(2‐hydroxyethyl)‐thiourea labelled with ^14^C at its urea group was synthesised starting from potassium cyanide‐^14^C, via potassium thiocyanate‐^14^C, 4‐chlorobenzyl‐thiocyanate‐^14^C and 4‐chlorobenzyl‐isothiocyanate‐^14^C. The conditions of the isomerisa