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Synthesis of tritium labeled pramiracetam (CI-879; N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide)

✍ Scribed by J. H. Dodd; F. M. Hershenson; J. L. Hicks; D. E. Butler; E. P. Lewis; C. C. Huang

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
231 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

Prami racetam (C 1-879; N-CP-Cbi s ( 1-met hyl e t h y l ) ami n o l e t h y l I-2-0x0-1p y r r o l i d i n e a c e t a m i d e ) was r a d i o l a b e l e d w i t h tritium. e t h y l 2,5-di hydro-2-oxo-l~-pyrrole-l-acetate i n t h e presence o f PdfC gave e t h y l 2-0~0-1-[3,4-3H]pyrrolidineacetate. w i t h fl,l-bis( l-methylethyl)-1,2-ethanediamine gave pramiracetam, which was

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