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Synthesis of conformationally constrained peptides via solid-phase incorporation of the constraints

✍ Scribed by Gábor K. Tóth; Zoltán Kele; Ferenc Fülöp

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 72 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01795-0

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✦ Synopsis

A simple solid-phase method has been developed, in which Pictet-Spengler cyclization is applied on resin for the synthesis of some conformationally constrained tripeptides. This methodology was also used for the synthesis of oxytocin antagonist analogues.

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