𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The use of norbornene derivatives in the synthesis of conformationally constrained peptides and pseudo-peptides

✍ Scribed by Iwan G. Jones; Michael North

Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
193 KB
Volume
5
Category
Article
ISSN
1573-3149

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Synthesis of conformationally constraine
Synthesis of conformationally constrained peptides via solid-phase incorporation of the constraints
✍ GΓ‘bor K. TΓ³th; ZoltΓ‘n Kele; Ferenc FΓΌlΓΆp πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 72 KB

A simple solid-phase method has been developed, in which Pictet-Spengler cyclization is applied on resin for the synthesis of some conformationally constrained tripeptides. This methodology was also used for the synthesis of oxytocin antagonist analogues.

Piperazine-2,3,5-triones in the synthesi
Piperazine-2,3,5-triones in the synthesis of constrained peptides
✍ Patrick D. Bailey; Andrew N. Boa; S.Richard Baker; Joanne Clayson; Ernest J. Mur πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 251 KB

Amino acid amides react with diethyl oxalate and sodium ethoxide to yield 6-substituted piperazine-2,3,5triones, which can be mono-alkylated at N 4, bis-alkylated at N 4 and C 6, or tris-alkylated at N 4, N 1, and C 6 under mild basic conditions; this provides access to i) ct,a-disubstituted cyclic