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Incorporation of Cα-methyl amino acids by solid phase peptide synthesis in a peptide sequence

✍ Scribed by Alié Brunissen; Mimoun Ayoub; Solange Lavielle

Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 264 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)01507-9

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✦ Synopsis

S)-ctMethyimethionine, (S)-ctMethylleucine, 2-aminoisobutyric acid and (S)-otMethylphenylalanine have been incorporated by solid phase peptide strategy in a peptide sequence.

The coupling reactions of these Boc-ctMe amino acids and of the following residue in the sequence were readily achieved after silylation with chlorotrimethylsilane of the amine function on the resin.

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