✦ LIBER ✦

Peptide modification by incorporation of α-trifluoromethyl substituted α-amino acids

✍ Scribed by Klaus Burger; Norbert Sewald; Christian Schierlinger; Kerstin Mütze; Liza C. Seymour

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 23 KB
Volume: 54
Category: Article
ISSN: 0022-1139
DOI: 10.1016/s0022-1139(00)83708-2

No coin nor oath required. For personal study only.

✦ Synopsis

a-Trifluoromethyl a-amino acids are potentially intaresting candidates for modification of biological active peptides. We report on new strategies for asymmetric synthesis of a-trifluoromethyl substituted a-amino acids. Approaches to amino group protection and carboxylic group activation are presented.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis and Incor

ChemInform Abstract: Synthesis and Incorporation of α-Trifluoromethyl-Substituted Amino Acids into Peptides

✍ B. KOKSCH; N. SEWALD; H.-D. JAKUBKE; K. BURGER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

Peptide modification by introduction of

Peptide modification by introduction of α-trifluoromethyl α-amino acids via 4-trifluoromethyl-1,3-oxazolidin-2,5-diones

✍ Christian Schierlinger; Klaus Burger 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 140 KB

Peptide Synthesis with α-(Difluoromethyl

Peptide Synthesis with α-(Difluoromethyl)-Substituted α-Amino Acids.

✍ Thomas Michel; Beate Koksch; Sergei N. Ospov; Alexander S. Golubev; Joachim Siel 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 58 KB 👁 1 views

Proteolytically stable peptides by incor

Proteolytically stable peptides by incorporation of α-Tfm amino acids

✍ Beate Koksch; Norbert Sewald; Hans-Jörg Hofmann; Klaus Burger; Hans-Dieter Jakub 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB 👁 1 views

A series of model peptides containing a-trifluoromethyl-substituted amino acids in five different positions relative to the predominant cleavage site of the serine protease a-chymotrypsin was synthesized by solution methods to investigate the influence of a-Tfm substitution on the proteolytic stabil

A novel synthetic route to α-trifluorome

A novel synthetic route to α-trifluoromethyl substituted α-amino acids

✍ K. Burger; K. Gaa; K. Geith 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 37 KB

ChemInform Abstract: Incorporation of α-

ChemInform Abstract: Incorporation of α-Trifluoromethyl Substituted α-Amino Acids into C- and N-Terminal Position of Peptides and Peptide Mimetics Using Multicomponent Reactions.

✍ K. BURGER; K. MUETZE; W. HOLLWECK; B. KOKSCH 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 41 KB 👁 1 views