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A novel synthetic route to α-trifluoromethyl substituted α-amino acids

✍ Scribed by K. Burger; K. Gaa; K. Geith


Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
37 KB
Volume
45
Category
Article
ISSN
0022-1139

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Peptide modification by incorporation of
✍ Klaus Burger; Norbert Sewald; Christian Schierlinger; Kerstin Mütze; Liza C. Sey 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 23 KB

a-Trifluoromethyl a-amino acids are potentially intaresting candidates for modification of biological active peptides. We report on new strategies for asymmetric synthesis of a-trifluoromethyl substituted a-amino acids. Approaches to amino group protection and carboxylic group activation are present