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Incorporation of 2-hydroxy-4-methoxybenzyl protection during peptide synthesis via reductive alkylation on the solid phase

✍ Scribed by Nicholas J. Ede; Kiah How Ang; Ian W. James; Andrew M. Bray

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
208 KB
Volume
37
Category
Article
ISSN
0040-4039

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✦ Synopsis

A method has been developed for the synthes/s ~'lhnb protected atuino acid residues via reductive alkylation of 2-hydroxy-4-melhoxybenzaldehyde with resin bound amino acids/peptides. The methodology potentially allows incorporation of limb protected atuino acids at any point in the synthesis of difficult peptides.

, illustrates the method

📜 SIMILAR VOLUMES

Synthesis and purification of aggregatio
Synthesis and purification of aggregation-prone hydrophobic peptides by the incorporation of an Fmoc dipeptide with the peptide bond protected with a modified 2-hydroxy-4-methoxybenzyl (Hmb) group
✍ Karolina Wahlström; Ove Planstedt; Anders Undén 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 218 KB

The dipeptide Fmoc-Val-(2-hydroxy-4-methoxybenzyl)Gly-OBzl was synthesized and the 2-hydroxyl group carbamoylated to give a Boc-N(CH 3 )CH 2 CH 2 N(CH 3 )CO-, (Boc-Nmec-) modification of the 2-hydroxy-4-methoxybenzyl (Hmb) group. After catalytic hydrogenation and purification, the resulting dipeptid