𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The incorporation of β-turn prosthetic units into merrifield solid phase peptide synthesis

✍ Scribed by Michael Kahn; Stephen Bertenshaw

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
186 KB
Volume
30
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The incorporation of designed conformationally restricted nonpeptide p-turn prosthetic units onto the amino terminus of peptides is discussed. The s mimetic was accomphshed using Merrifield soh J Ethesis of the peptides, including the incorporation of the p-turn phase autoniated peptide synthesis.

📜 SIMILAR VOLUMES

Synthesis of conformationally constraine
Synthesis of conformationally constrained peptides via solid-phase incorporation of the constraints
✍ Gábor K. Tóth; Zoltán Kele; Ferenc Fülöp 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 72 KB

A simple solid-phase method has been developed, in which Pictet-Spengler cyclization is applied on resin for the synthesis of some conformationally constrained tripeptides. This methodology was also used for the synthesis of oxytocin antagonist analogues.

Incorporation of a phosphonic acid isost
Incorporation of a phosphonic acid isostere of aspartic acid into peptides using Fmoc-solid phase synthesis
✍ P.A. Lohse; R. Felber 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 229 KB

A short synthesis of a novel Fmoc-derivative 2b of the phosphonic acid isostere I of aspartic acid is presented. Incorporation of 2b into peptides was readily achieved using standard Fmoc-solid phase synthesis. Efficient removal of the allyl protecting groups after sequence assembly under mild condi

A rapid method for the preparation of am
A rapid method for the preparation of amino acid resin esters for merrifield solid-phase peptide synthesis
✍ Michael W. Monahan; Chaim Gilon 📂 Article 📅 1973 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 389 KB 👁 2 views

## Abstract An improved method for the preparation of Merrifield resin esters is presented. This method is rapid, is free of racemization, and is not complicated by a quaternization side reaction. Chloromethylated resin beads, __t__‐butoxycarbonyl amino acid, and potassium __t__‐butoxide are heated