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Incorporation of a phosphonic acid isostere of aspartic acid into peptides using Fmoc-solid phase synthesis

✍ Scribed by P.A. Lohse; R. Felber

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
229 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A short synthesis of a novel Fmoc-derivative 2b of the phosphonic acid isostere I of aspartic acid is presented. Incorporation of 2b into peptides was readily achieved using standard Fmoc-solid phase synthesis. Efficient removal of the allyl protecting groups after sequence assembly under mild conditions using Pd(0) catalysis afforded phosphonopeptides 3a and 3b in high purity.

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