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Solid-phase synthesis of potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere

✍ Scribed by Jinglan Zhou; Andreas Termin; Melissa Wayland; Christine M. Tarby

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 189 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00351-2

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✦ Synopsis

A series of 1,3-diamino-2-propanol derivatives have been synthesized on solid phase as potential aspar'tic acid protease irdaibitors. The developed methodology allows the incorporation of either an alkyl group or H at the R 2 site of hydroxyethylamine isostere.

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