Solid phase synthesis of a diketopiperazine catalyst containing the unnatural amino acid (S)-norarginine
β Scribed by Jennifer Kowalski; Mark A. Lipton
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 126 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Barton esters were prepared starting from different carboxylic acids loaded on a Wang resin. Light induced fragmentation occurred giving a radical that reacted with CBrCl 3 to give the corresponding bromides, whereas conjugate addition to electron-poor alkenes proved to be less synthetically useful.
## Abstract An icosapeptide, **1**, containing the __Ξ²__^3^βamino acid residues with the 20β proteinogenic side chains has been assembled by manual solidβphase synthesis, according to the Fmoc strategy. The sequence was chosen in such a way that a possible __3__~14~βhelical conformation (secondary s