Solid Phase Synthesis of β-Peptides via Arndt-Eistert Homologation of Fmoc-Protected Amino Acid Diazoketones
✍ Scribed by Roger E Marti; Konrad H Bleicher; Kenneth W Bair
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 528 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amino acid derivatives protected at the a-or side chain amino function with mono-as well as dimethoxytrityl were successfully prepared by a one-step procedure. These derivatives were evaluated for their utilization in solid phase peptide synthesis (SPPS), particularly with respect to the selective d
## Abstract The successful application of the __Arndt‐Eistert__ protocol starting from commercially available __N__‐{[(9__H__‐fluoren‐9‐yl)methoxy]carbonyl}‐protected (Fmoc) α‐amino acids leading to enantiomerically pure __N__‐Fmoc‐protected β‐amino acids in only two steps and with high yield is re