Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic

✍ Scribed by Wim M De Borggraeve; Frederik J.R Rombouts; Erik V Van der Eycken; Suzanne M Toppet; Georges J Hoornaert

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 84 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01080-2

✦ Synopsis

Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels-Alder strategy. The b-turn characteristics of molecule 8 were examined by molecular modeling and NMR spectroscopy.