Synthesis of benzo-fused, 7,5- and 7,6-fused azepinones as conformationally restricted dipeptide mimetics
β Scribed by Jeffrey A. Robl; Donald S. Karanewsky; Magdi M. Asaad
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 246 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Using a convenient and practical route we report the preparation of a series of rigid surrogates of amino acids and dipeptides for application within constrained peptide analogues, and for employment as input for combinatorial science. These substituted 2-oxo-1azabicycloalkane amino acids have the p
The flmt short syntheds of the @eptIde mimetic (3s. 8S. SS)-8-amlnc-6-oxctndotiridiW-cafhoxyfk add 1 and its zpmtected dedvatlve 9 is described, empkyfng the Schoallkcpf bkkctim-ether methodokgy, folkwed by a highly specific lntramokcufar reductive afnfnatkn and spontaneous kctamizatlon. These W-fus
Chemo-selective reduction of the pyroglutamate ring carbonyl in a serine-pyroglutamate or homoserine to pyroglutamate dipeptide gave a hemiaminal. Treatment of the hemiaminal with a catalytic amount of TFA in CH 2 Cl 2 generated an N-acyliminium ion that was intramolecularly trapped by the side-chai