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Synthesis of substituted conformationally constrained 6,5- and 7,5-fused bicyclic lactams as dipeptide mimics

โœ Scribed by Erica Artale; Gaia Banfi; Laura Belvisi; Lino Colombo; Matteo Colombo; Leonardo Manzoni; Carlo Scolastico

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
324 KB
Volume
59
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Using a convenient and practical route we report the preparation of a series of rigid surrogates of amino acids and dipeptides for application within constrained peptide analogues, and for employment as input for combinatorial science. These substituted 2-oxo-1azabicycloalkane amino acids have the potential of replicating the backbone geometry and side-chain function of dipeptide residues like serine, lysine, glutamate, and related amino acids.

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