Conformationally constrained dipeptides: Synthesis of 7,5- and 6,5-fused bicyclic lactams by stereoselective radical cyclizations
โ Scribed by Lino Colombo; Marcello Di Giacomo; Carlo Scolastico; Leonardo Manzoni; Laura Belvisi; Valentina Molteni
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 211 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Using a convenient and practical route we report the preparation of a series of rigid surrogates of amino acids and dipeptides for application within constrained peptide analogues, and for employment as input for combinatorial science. These substituted 2-oxo-1azabicycloalkane amino acids have the p
Chemo-selective reduction of the pyroglutamate ring carbonyl in a serine-pyroglutamate or homoserine to pyroglutamate dipeptide gave a hemiaminal. Treatment of the hemiaminal with a catalytic amount of TFA in CH 2 Cl 2 generated an N-acyliminium ion that was intramolecularly trapped by the side-chai