A convenient and versatile synthesis of
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Xiaojun Zhang; Wen Jiang; Aaron C. Schmitt
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Article
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2001
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Elsevier Science
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French
โ 60 KB
Chemo-selective reduction of the pyroglutamate ring carbonyl in a serine-pyroglutamate or homoserine to pyroglutamate dipeptide gave a hemiaminal. Treatment of the hemiaminal with a catalytic amount of TFA in CH 2 Cl 2 generated an N-acyliminium ion that was intramolecularly trapped by the side-chai