Bicyclic turned dipeptide (BTD) as a β-turn mimetic; its design, synthesis and incorporation into bioactive peptides

Design and synthesis of a cis-gly-pro, t

Design and synthesis of a cis-gly-pro, type-VI turn, dipeptide mimetic and its use in fmoc-solid phase peptide synthesis

✍ Dieter Gramberg; John A. Robinson 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 387 KB

The Fmoc-protected bicyclic mobxuks 7 and 8 have been produced as cti-Gly-Ro peptide mimetics in nine synthetic steps st&n8 from q&ally pure (It)-2-allylproline. The& ose in solid-phase peptick synthesis has been dunon@ated by their incorpowtion into analo8w of ci.&ly%?-brrdykinin.