The cyclizatlon of the linear hydroxyethylene isostere based HIV-PR inhibitors gave the delta lactam XQ921, which was found to have a K i = 9.4 uM. It is proposed that a major reason for the weaker potency of the lactam XQ921 compared to cycliv urea based inhibitors is the lack of a PI' substituent
✦ LIBER ✦
Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor
✍ Scribed by Zhijun Wu; Gunda I. Georg; Brian E. Cathers; John V. Schloss
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 205 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
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