✦ LIBER ✦

ChemInform Abstract: Design and Synthesis of Monocyclic β-Lactams as Mechanism-Based Inhibitors of Human Cytomegalovirus Protease.

✍ Scribed by A. D. BORTHWICK; G. WEINGARTEN; T. M. HALEY; M. TOMASZEWSKI; W. WANG; Z. HU; J. BEDARD; H. JIN; L. YUEN; T. S. MANSOUR

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199821217

No coin nor oath required. For personal study only.

✦ Synopsis

Design and Synthesis of Monocyclic β-Lactams as Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. -Starting from monocyclic β-lactams novel human cytomegalovirus protease inhibitors, e.g. (III), (VII),and (VIII), are developed. The most potent one among them is the derivative (VII) with good stability to hydrolysis and good selectivity in low µmol ranges. -(BORTHWICK, A.

📜 SIMILAR VOLUMES

Design and Synthesis of Pyrrolidine-5,5-

Design and Synthesis of Pyrrolidine-5,5-trans-lactams as Novel Mechanism Based Inhibitors of Human Cytomegalovirus Protease

✍ W. Michael Seganish; Bruce B. Jarvis 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 4 KB 👁 1 views

ChemInform Abstract: Inhibition of Human

ChemInform Abstract: Inhibition of Human Cytomegalovirus Protease N0 with Monocyclic β-Lactams.

✍ R. DEZIEL; E. MALENFANT 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB

ChemInform Abstract: Metal Mediated Prot

ChemInform Abstract: Metal Mediated Protease Inhibition: Design and Synthesis of Inhibitors of the Human Cytomegalovirus (hCMV) Protease.

✍ Dashyant Dhanak; George Burton; Lisa T. Christmann; Michael G. Darcy; Kyle C. El 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of Novel Monocyclic β-Lactam Inhibitors of Prostate Specific Antigen.

✍ R. M. ADLINGTON; J. E. BALDWIN; B. CHEN; S. L. COOPER; W. MCCOULL; G. J. PRITCHA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB

Pyrrolidine-5,5-trans-lactams as Novel M

Pyrrolidine-5,5-trans-lactams as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. Part 3. Potency and Plasma Stability.

✍ Alan D. Borthwick; Anne M. Exall; Terry M. Haley; Deborah L. Jackson; Andrew M. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

ChemInform Abstract: Solution-Phase Synt

ChemInform Abstract: Solution-Phase Synthesis of a Combinatorial Monocyclic β-Lactam Library: Potential Protease Inhibitors.

✍ J. PITLIK; C. A. TOWNSEND 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB