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Design and Synthesis of Pyrrolidine-5,5-trans-lactams as Novel Mechanism Based Inhibitors of Human Cytomegalovirus Protease

โœ Scribed by W. Michael Seganish; Bruce B. Jarvis


Publisher
John Wiley and Sons
Year
2003
Weight
4 KB
Volume
34
Category
Article
ISSN
0931-7597

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Design and Synthesis of Monocyclic ฮฒ-Lactams as Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. -Starting from monocyclic ฮฒ-lactams novel human cytomegalovirus protease inhibitors, e.g. (III), (VII),and (VIII), are developed. The most potent one among them is the derivative (VII) with