The synthesis of a new 3-hydroxy-3-methylglutaryl coenzyme A reduc-----tase inhibitor starting from 4,4' -difluorobenzophenone is described. Mevinolin 1 and its congeners are potent inhibitors of 3-hydroxy-3-methyl-
Synthesis of 6-(R)-hydroxy-7,9-octadecadiynoic acid, a HMG-CoA reductase inhibitor
β Scribed by S.Y. Mhaskar; G. Lakshminarayana
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 117 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The synthesis of the B-hydroxy-6 -1actone moiety of an HMG-CoA reductase inhibitor in its correct absolute configuration (94% ee) has been accomplished via a diastereoselective aldol reaction enolate of S(+)1,2,2-triphenylethylacetate, between aldehyde 4 and the magnesium Claisen condensation, direc
The synthesis of a new fluoro-substituted 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor 2 in high optical purity via addition of the chiral enolate 12 to fluoro aldehyde 82 is described.
The coupling of acyl anion equivalent 12b with chiral synthon 14, derived from isoascorbic acid, and a highly stereospecific reduction of the resulting e-Tydroxy ketone 3 highlight an efficient synthesis of 8-hydroxy-&lactone 2. -
Abstmet: Upon exposure to intense simulated sunlight, CI-981 (1) readily decomposes into three major by-products. This paper reports on the products formed when I is decomposed in acetommlelwater solutions under intense simulated sunlight, ult~~~olet b&t filtered at 254 mn and visible light, In&ded