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A diastereospecific, non-racemic synthesis of a novel β-hydroxy-δ-lactone HMG-CoA reductase inhibitor

✍ Scribed by M. Sletzinger; T.R. Verhoeven; R.P. Volante; J.M. McNamara; E.G. Corley; T.M.H. Liu

Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
232 KB
Volume
26
Category
Article
ISSN
0040-4039

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✦ Synopsis

The coupling of acyl anion equivalent 12b with chiral synthon 14, derived from isoascorbic acid, and a highly stereospecific reduction of the resulting e-Tydroxy ketone 3 highlight an efficient synthesis of 8-hydroxy-&lactone 2.

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