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Development of a Practical Synthesis of Novel, Pyrrole-Based HMG-CoA Reductase Inhibitors.

โœ Scribed by Jeffrey A. Pfefferkorn; Daniel M. Bowles; William Kissel; David C. Boyles; Chulho Choi; Scott D. Larsen; Yuntao Song; Kuai-Lin Sun; Steven R. Miller; Bharat K. Trivedi

Publisher
John Wiley and Sons
Year
2007
Weight
14 KB
Volume
38
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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Peptide design of a competitive inhibito
Peptide design of a competitive inhibitor for HMG-CoA reductase based on statin structure
โœ Valeriy V. Pak; Sung Hee Kim; Minseon Koo; Nari Lee; K. M. Shakhidoyatov; Dae Yo ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 269 KB ๐Ÿ‘ 2 views

## Abstract This study investigates a proposed design of a peptide sequence that is based on a bioactive conformation of statins that act as the competitive inhibitors of HMGโ€“CoA for HMGR. To bridge these heterogeneous organic compounds, a conformational aspect relating to an analysis of the flexib