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Synthesis of a novel HMG-COA reductase inhibitor

✍ Scribed by E. Baader; W. Bartmann; G. Beck; A. Bergmann; H. Jendralla; K. Kesseler; G. Wess; W. Schubert; E. Granzer; B.V. Kerekjarto; R. Krause

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
120 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of a new 3-hydroxy-3-methylglutaryl coenzyme A reduc-----tase inhibitor starting from 4,4' -difluorobenzophenone is described. Mevinolin 1 and its congeners are potent inhibitors of 3-hydroxy-3-methyl-

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