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Synthesis of novel HMG-CoA reductase inhibitors, II. Heterocyclic analogs of mevinolin

✍ Scribed by Novák, Lajos ;Hornyánszky, Gábor ;Rohály, János ;Kolonits, Pál ;Szántay, Csaba

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
850 KB
Volume
1995
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The indole (1) and chroman analogs (2) of mevinolin and their 6__S__ diastereomers 15c and 25d were synthesized in several steps starting with methyl (R)‐3‐[(tert‐butyldimethylsilyl)oxy]‐4‐formylbutyrate (12) and 2‐(indol‐3‐yl)ethanol (3) or 6‐methoxychroman‐4‐one (16), respectively. Compounds 1 and 2 inhibited moderately the HMG‐CoA reductase. The diastereomers 15c and 25d were shown to be inactive.

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