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Synthesis of an HMG-CoA reductase inhibitor; a diastereoselective aldol approach

✍ Scribed by J.E Lynch; R.P Volante; R.V Wattley; I Shinkai

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 176 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)95933-1

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✦ Synopsis

The synthesis of the B-hydroxy-6 -1actone moiety of an HMG-CoA reductase inhibitor in its correct absolute configuration (94% ee) has been accomplished via a diastereoselective aldol reaction enolate of S(+)1,2,2-triphenylethylacetate, between aldehyde 4 and the magnesium Claisen condensation, directed reduction of the resulting 6-hydroxy-B-keto ester. and hydroxyl

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