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Synthesis of [15N]t-butylamine hydrochloride

✍ Scribed by Yingdan Zhang; Chaojie Lin; Zhan Li; Liqiong Qin; Hongliang Wen

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
86 KB
Volume
53
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

This report presents an efficient synthesis of [^15^N]t‐butylamine hydrochloride. Acylation of [^15^N]ammonia with pivaloyl chloride provided [^15^N]pivalamide, this was converted to benzyl [^15^N]N‐t‐butylcarbamate through a Hofmann rearrangement. Hydrogenolysis of benzyl [^15^N]N‐t‐buylcarbamate and acidification afforded [^15^N]t‐butylamine hydrochloride in an overall yield of 79.2% in four steps. Copyright © 2010 John Wiley & Sons, Ltd.

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