A colorimetric assay procedure was developed for the quantitative analysis of procaine hydrochloride. The method is based on the interaction of procaine hydrochloride with p-dimethylaminocinnamaldehyde in the presence of trichloroacetic acid in absolute methanol to form a red Schiff base which can b
Synthesis of [15N]-procaine hydrochloride
β Scribed by Maria Chiriac; Smaranda Pop; Elisabeta Dordea
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 215 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
The synthesis of [^15^N]β labelled procaine hydrochloride, using (^15^NH~4~)~2~SO~4~ as starting isotopically labelled material, is presented. The experimental procedure is an adaptation of the synthesis methods for the corresponding unlabelled compounds.
π SIMILAR VOLUMES
## Abstract This report presents an efficient synthesis of [^15^N]tβbutylamine hydrochloride. Acylation of [^15^N]ammonia with pivaloyl chloride provided [^15^N]pivalamide, this was converted to benzyl [^15^N]Nβtβbutylcarbamate through a Hofmann rearrangement. Hydrogenolysis of benzyl [^15^N]Nβtβbu
## Abstract 1β[^15^N]Aminoβ2βpropanol hydrochloride (**2**) was synthesized in three steps, i.e. Gabriel condensation of potassium [^15^N]phthalimide (**3**) with chloroacetone (**4**), reduction of the product ([^15^N]phthalimidoacetone (**5**)) with sodium borohydride, and hydrolysis in 33% total
A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react with 1,2-napht
Aqueous solutions of procaine hydrochloride containing sodium forrnaldehydesulfoxylate as a preservative are not stable to heat sterilization as measured by the U. S. P. XIV method of assay for procaine. A condensation product of these two chemicals was synthesized and found to be a stable crystalli