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Colorimetric analysis of procaine hydrochloride

โœ Scribed by Henry S. I. Tan; D. Shelton

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
390 KB
Volume
63
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

A colorimetric assay procedure was developed for the quantitative analysis of procaine hydrochloride. The method is based on the interaction of procaine hydrochloride with p-dimethylaminocinnamaldehyde in the presence of trichloroacetic acid in absolute methanol to form a red Schiff base which can be quantitated spectrophotometrically a t 547.5 nm. The Beer-Lambert law was adhered to over the 0.1-7-pg/ml range. Best accuracy was attained for solutions containing 0.4-4 pg/ml. The color was stable for at least 70 min. The method was applied to pro-caine hydrochloride injections, both with and without epinephrine, without prior separation of the drug. The results were comparable to those obtained by the official procedures.

Keyphrases o Procaine hydrochloride-colorimetric analysis using p -d i m e thylaminocinnamaldehyde o p-Dimethylaminocinnamaldehyde-colorimetric reagent for determination of procaine hydrochloride Colorimetry-determination, procaine hydrochloride, using p-dimethylaminocinnamaldehyde

๐Ÿ“œ SIMILAR VOLUMES

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