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The Reaction of Procaine Hydrochloride with Sodium Formaldehydesulfoxylate*

✍ Scribed by Hardie, W.R. ;Williams, A.R. ;Halverstadt, I.F. ;Johnson, Frederick F.

Publisher
Elsevier
Year
1954
Weight
287 KB
Volume
43
Category
Article
ISSN
0095-9553

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✦ Synopsis

Aqueous solutions of procaine hydrochloride containing sodium forrnaldehydesulfoxylate as a preservative are not stable to heat sterilization as measured by the U. S. P. XIV method of assay for procaine. A condensation product of these two chemicals was synthesized and found to be a stable crystalline water-soluble zwitterion with the formula ClrHa~N~O&2H~0. The compound exhibits DO local anesthetic activity and no acute toxicity in high doses.

N THE PREPARATION of aqueous procaine hy-*

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