Aqueous solutions of procaine hydrochloride containing sodium forrnaldehydesulfoxylate as a preservative are not stable to heat sterilization as measured by the U. S. P. XIV method of assay for procaine. A condensation product of these two chemicals was synthesized and found to be a stable crystalli
Study of the color reaction of streptomycin sulfate with procaine hydrochloride
✍ Scribed by A. V. Puccini; A. J. Spiegel
- Publisher
- John Wiley and Sons
- Year
- 1962
- Tongue
- English
- Weight
- 188 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The cause of the increased color of streptomycin sulfate solution i n the presence of procaine hydrochloride was studied. I t was determined that the carbonyl function of the streptomycin reacted with the p-amino group of the procaine causing a discoloration beyond that of a normal streptomycin solution.
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